Diagnosis of Macrovascular Complications in Diabetes Mellitus Using Arterial Stiffness Measured by the Cardio-Ankle Vascular Index

Diagnosis of Macrovascular Complications in Diabetes Mellitus Using Arterial Stiffness Measured by the Cardio-Ankle Vascular Index



Mao Takahashi1,*, Kazuhiro Shimizu1, Takuo Iizuka1, Shyuuji Satou1, Mahito Noro1, Tomoaki Shiba2 and Kohji Shirai3

1Department of Cardiovascular Center, Sakura Hospital, Medical Center, Toho University, Chiba, Japan
2Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan
3Department of Vascular Function Laboratory, Sakura Hospital, Medical Center, Toho University Chiba, Japan



Journal of Aging Science



Arterial anti-aging treatment is important, but there had not been a good marker of arterial aging. One candidate of the markers was arterial stiffness. But, it has been difficult to measure proper arterial stiffness in vivo, noninvasively. Pulse wave velocity (PWV) which was reflecting arterial stiffness, was used for last 30 years, but was inherently changed at the blood pressure at measuring time. The cardio-ankle vascular index (CAVI) was recently developed marker reflecting arterial stiffness of the arterial tree from the origin of the aorta to the ankle. The
conspicuous feature of CAVI is independency from the blood pressure at measuring time.


CAVI increased with aging both in males than in females. So, CAVI could be a good marker reflecting arterial aging. Furthermore, CAVI showed high value in most of those with various risks of coronary artery disease, and especially high in those with diabetes mellitus and even with prediabetes condition. Diabetes mellitus is kwon to be a strong factor for arterial aging. Recently, many studies showed that CAVI was improved by some of various diabetic
treatments, indicating that CAVI might be an indicator of the treatment for diabetic angiopathy. Those also suggested that CAVI could be an indicator of various strategies especially controlling diabetes mellitus, in preventing, delaying vascular aging.



Aging; Arterial stiوٴness; Cardiovascular risk factor; Cardio-ankle vascular index




PWV: Pulse Wave Velocity; CAVI: Cardiac-ankle Vascular Index; ONH: Optic Nerve Head; Pd: Diastolic blood pressure; Ps: Systolic blood pressure; PWV: Pulse Wave Velocity.


Read the whole study in the PDF file BELOW



© 2017 Takahashi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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