Exploration of a novel antidiabetic regimen by concomitant use of synthetic and herbal drugs

Exploration of a novel antidiabetic regimen by concomitant use of synthetic and herbal drugs



7th Epidemiology and Public Health Conference


Bharat Mishra,

Nirmala College of Pharmacy, India



Diabetes Mellitus (DM) has assumed the status of an epidemic resulting in total estimated expenditures for diabetes approaching $132 billion. The rise in diabetic patients from 171 million in 2000 to 366 million in 2030 is projected. Available treatment of DM helps lower blood sugar in a different way and shows serious side effects. Not only the economy but also the prominent side-effects of such drugs are the main reason for increasing interest in alternative therapies with less severe or no side-effects. The herbal drugs show delayed onset of action as compared with synthetic drugs while the synthetic drugs exhibit more side effects, therefore, some novel therapeutic combinations of synthetic and herbal drugs are being investigated for better effects viz. reducing the dose, cost, and side effects. The present investigation explores the effect of concomitant use of aqueous leaf extract of Gymnema Sylvestre (GS) and Momordica Charantia (MC) in combination with different fractions of Pioglitazone (PGL) in high fat-fed and Streptozotocin (STZ) induced type-2 diabetic albino rats. Diabetic rats were treated with extracts of GS and MC with reducing doses of PGL and parameters like blood glucose level, kidney function, body weight, organ weight & urine volume were observed at different time intervals for a period of 40 days. The combination was found to control the blood glucose levels to a greater extent as compared to the synthetic drug. It was also observed that there was an improvement in diabetes-associated complications. The psychological, biochemical and histopathological results indicated that the combination has shown better hepatoprotective, renoprotective and neuroprotective effects as compared to PGL alone.



Bharat Mishra has completed his PhD from Jodhpur National University and Masters in Pharmacology from Rajiv Gandhi University of Health Sciences, India. He is currently working as the Professor and Head of the Department of Pharmacology at Nirmala College of Pharmacy, India. He has published more than 25 papers in reputed journals and has been serving as an Editorial Board Member of repute.