Roche's Tecentriq cocktail scores trial success in melanoma

Roche's Tecentriq cocktail scores trial success in melanoma

A late-stage clinical trial has shown therapy combining Roche’s immunotherapy Tecentriq with two of its other drugs helped people with a form of advanced melanoma, the Swiss drugmaker said on Friday,  Reuters reports.


The study met its primary aim of showing progression-free survival in patients with previously untreated BRAF V600 mutation-positive advanced melanoma, Roche said.


Adding Tecentriq, a monoclonal antibody, to Cotellic and Zelboraf helped reduce the risk of disease worsening or death compared to administering a placebo plus Cotellic and Zelboraf.


By combining a cancer immunotherapy with targeted therapies, we hope to offer a new approach that improves outcomes for people with advanced, BRAF-mutant melanoma,” said Levi Garraway, Roche’s chief medical officer and head of product development.

Roche has an extensive clinical trial development program for Tecentriq, with more than 50 studies for use in fighting lung, kidney, skin, breast, colorectal, prostate, ovarian, bladder, blood, liver and head and neck cancers.


Tecentriq immunotherapy mixed with chemotherapy won U.S. approval this month as an initial treatment for a form of lung cancer as Roche seeks to establish its alternative to drugs from Merck and Bristol-Myers Squibb.