Keratoderma as a paraneoplastic sign on NSCLC patient

Keratoderma as a paraneoplastic sign on NSCLC patient



Esti Shamba1*, Ephraim Shamba2 and Nir Peled3


1Research Coordinator, Institute of Pulmonology, Schneider Children's Medical Center of Israel, Israel

2Family physician, Clalit Health Services, Jerusalem, Israel

3Head, Institute of Oncology, Soroka Medical Center, Ben-Gurion University, Beer Sheva, Israel



Dermatology Case Reports



Palmoplantar keratoderma is a dermatosis that presents as hyperkeratosis of the palms and soles. Skin disorders of the feet can affect the glabrous skin on the dorsal aspects, or the thick skin on the plantar aspectsthereof, or both. Some can affect one foot, and others both. These diseases can be inflammatory, genetically inherited, infectious orneoplastic in origin. It is important to identify them and to start treatment early. If not treated, some may lead to severe pain on walking, inability to wear shoes, or even amputation with serious disability.


We present a patient with severe treatment-resistant keratoderma of the feet, in addition to a long-standing dry cough. Because of the cough, a CT scan of the chest was done and a 2.5×2.5 cm nodule was detected in the left lower lobe of the lung. A biopsy confirmed the diagnosis of non-small cell lung cancer (NSCLC) stage IA. It was resected entirely with left lower lobectomy. The keratoderma resolved spontaneously within a few weeks of surgery.



NSCLC; Keratoderma; Hyperkeratosis


Read the whole article in the PDF file BELOW


© 2018 Shamba E. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited.

Fișiere atașate