The Evaluation of the Efficacy of Derivatives of Vitamin K

The Evaluation of the Efficacy of Derivatives of Vitamin K



Agata Markiewicz1 *, Bożena Tyszczuk2, Monika Pasikowska-Piwko2, Konrad Zieliński3, Anna Rkiert-Polguj4 and Elżbieta Budzisz1


1Department of Cosmetic Raw Materials Chemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland

2Dr Irena Eris Cosmetic Laboratories, Dr Irena Eris Center for Science and Research, Warsaw, Poland

3Minisynthesis Department, Pharmaceutical Research Institute, Rydygiera 8, Warsaw, Poland

4Department of Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland



Journal of Clinical & Experimental Dermatology Research





The aim of the study was to evaluate the safety and effectiveness of cosmetic products containing two derivatives of vitamin K on skin with vascular problems.

Materials and methods: 


The study was conducted in two groups, 24 people, and the other included 22 participants, mean age 50. The participants applied creams twice a day for a period of 4 weeks. Creams were applied to the right half of the face-concentration of 0.5% and 0.1% on the left. The participants completed a questionnaire and a measurement was carried out using standardized Multi Probe Adapters (MPA) Courage-Khazaka and VISIA Canfield. 


Application creams with MQ and Epoxy MQ derivatives at a concentration of 0.1% and 0.5% had the effect of reducing redness of the skin at a comparable level. All of the formulations did not contribute to the decrease of melanin level. The hydration was increased after application MQ (0.1% and 0.5%) adequately 14% and 13% in about 60% of participants. The elasticity was significantly improved in all groups. 


Derivatives of vitamin K such as Epoxy MQ and MQ used in 0.1% and 0.5% give comparable results reducing redness of the skin. The improvement of erythema was more significant with 0.1% concentration (MQ and Epoxy MQ).



Vascular skin; erythema; Vitamin K; Cosmetic formulation; teleangiectasia


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Markiewicz A, Tyszczuk B, Piwko M, Zielinski K, Polguj AR, et al. (2018) J Clin Exp Dermatol Res 9: 455. DOI: 10.4172 / 2155-9554.1000455



© 2018 Markiewicz A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which allows unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.