Atypical erythema multiforme palmar plaques lesions due to Sars‐Cov‐2

Atypical erythema multiforme palmar plaques lesions due to Sars‐Cov‐2


H. Janah, A. Zinebi , J. Elbenaye



Journal of the European Academy of Dermatology and Venereology


The research team reports two patients with diagnosis of COVID‐19 presenting erythema multiforme (EM) lesions which could be another acral cutaneous manifestation due to SARS‐CoV‐2.


Erythema multiforme is immune‐mediated reaction that involves the skin and sometimes the mucosa due to infections, especially herpes simplex virus and mycoplasma pneumonia (MP), and medications like hydroxychloroquine. It consists of a polymorphous eruption of macules, papules and characteristic ‘target’ lesions that are symmetrically distributed with a propensity for the distal extremities.


First case


First case is a 17‐year‐old adolescent with no medical history, documented to have a mild SARS‐CoV‐2 infection for which he took vitamin C only. On the 15th day of the onset of symptoms, he developed erythematous maculopapular atypical targetoid eruption of palms only ( Fig. 1) . Lesions were painless and mild itching. There was no mucosal involvement. No recent episode of recurrent herpes was reported.



Second case


Second case is a 29‐year‐old man with no past medical history had been diagnosed with COVID‐19 and treated by hydroxychloroquine associated with azithromycin. He developed fixed and asymptomatic erythematous urticarial targetoid lesions on his palms



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